Label-free detection of single protein markers (molecules) of diseases, present in bodily fluids at ultra-low concentration is one of the primary interests of researchers working in the field of Biosensing. By early-stage detection of protein markers, many severe diseases can be cured. Nanoplasmonic-whispering gallery mode (WGM) hybrid microresonators work as highly efficient biosensing device which can be used to detect single protein molecules in real-time. In the hybrid microresonator, nanoplasmonic particles are used with the bare WGM microresonator. Here, we report (i) theoretical response of the nanoplasmonic-WGM hybrid microresonator in terms of frequency shift (reactive shift) using different nanoplasmonic particles, (ii) a comparative study of the responses of bare WGM and nanoplasmonic-WGM hybrid microresonators and (iii) experimental setups for detection of single protein molecules in real-time, present in our laboratory.

1.
F.
Vollmer
,
S.
Arnold
, and
D.
Keng
,
Proceedings of the National Academy of Sciences
,
105
(
52
),
20701
20704
(
2008
).
2.
J. D.
Swaim
,
J.
Knittel
and
W. P.
Bowen
,
Applied Physics Letters
,
99
(
4
),
243109
(
2011
).
3.
V. R.
Dantham
,
S.
Holler
,
C.
Barbre
,
D.
Keng
,
V.
Kolchenko
and
S.
Arnold
,
Nano Letters
,
13
(7),
3347
3351
(
2013
).
4.
J.
Knight
,
G.
Cheung
,
F.
Jacques
, and
T. A.
Birks
,
Optics Letters
,
22
(
1
),
1129
1131
(
1997
).
This content is only available via PDF.
You do not currently have access to this content.