Effect of different plasmonic nanoparticles on the reactive shift of nanoplasmonic-whispering gallery mode hybrid microresonator

Label-free detection of single protein markers (molecules) of diseases, present in bodily fluids at ultra-low concentration is one of the primary interests of researchers working in the field of Biosensing. By early-stage detection of protein markers, many severe diseases can be cured. Nanoplasmonic-whispering gallery mode (WGM) hybrid microresonators work as highly efficient biosensing device which can be used to detect single protein molecules in real-time. In the hybrid microresonator, nanoplasmonic particles are used with the bare WGM microresonator. Here, we report (i) theoretical response of the nanoplasmonic-WGM hybrid microresonator in terms of frequency shift (reactive shift) using different nanoplasmonic particles, (ii) a comparative study of the responses of bare WGM and nanoplasmonic-WGM hybrid microresonators and (iii) experimental setups for detection of single protein molecules in real-time, present in our laboratory.