Cloud point extraction of paracetamol in pharmaceutical formation coupling with spectrophotometric method Available to Purchase

This method shows a novel, fast and simple method and spectrophotometric procedure for preconcentration and determination of drugs, with Paracetamol being evaluated in this manner characterized easy, fast, and high sensitivity. Method to extract and estimate Paracetamol this method. which is based on the interaction between the drug and analytical reagent(m-nitroanillin) in the acid medium to form an intense reddish brown colour, ethanol-soluble consequent which can be readily extracted from micelles of a non-ionic surfactant (Triton X-114) and measured at the absorption maximum of 520 nm. The effect of salt out on the drug was also studied and the most important effect was NaIO₄ Where absorptivity increased significantly and increased wave length also increased intensity. The calibration curve establish the concentration range of [(5-500 µg/mL] with r=0.9964 and a molar absorptivity (0.0033) L.mol⁻¹.cm⁻¹. Limit of detection (LOD) and limit of quantification (LOQ) are (0.058, 0.19 µg/mL) respectively, the recoveries range (0.06). The method was successfully applied to the analysis of the (Paracetamol) in its pharmaceutical preparations.