S-layers are common cell surface structures in many Lactobacillus species and the primary structures of several lactobacillus S-layer proteins are currently known. The objective of this study was to investigate S-lays proteins of L. paracasei M7, which can be used as potential probiotics against pathogens infection. This research is aimed to elucidate if there is a relationship between Salmonella infection and S-lay proteins. Through analysis cell cycle by flow cytometry, the HT-29 cells treated by Salmonella in S phase were 26.88% compared with 36.70% the normal HT-29 cells. However, addition of S-layer proteins made the HT-29 cells in S phase increased to 30.13%. Moreover, we also found that Lactobacillus S-layer proteins could protected Salmonella-induced apoptosis through reduced the caspase-3 activity. This mechanism may represent a novel approach for antagonizing Salmonella infection. So this probiotics could be used in the health-promoting food products, which could prevent the diarrhea caused by Salmonella.
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19 February 2020
2ND INTERNATIONAL CONFERENCE ON FRONTIERS OF BIOLOGICAL SCIENCES AND ENGINEERING (FSBE 2019)
19–20 October 2019
Jinan City, China
Research Article|
February 19 2020
S-layer proteins from lactobacillus paracasei M7 mediated inhibition of Salmonella-induced apoptosis
Chaohui Xue;
Chaohui Xue
a)
1
College of Biological and Chemical Engineering, Nanyang Institute of Technology
. Nanyang 473000, China
a)Corresponding author email: 873790844@qq.com
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Le Yuan;
Le Yuan
b)
1
College of Biological and Chemical Engineering, Nanyang Institute of Technology
. Nanyang 473000, China
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Hongbo Li;
Hongbo Li
c)
2
School of Food Science and Engineering, Harbin Institute of Technology
, Harbin 150000, China
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Shumei Wang
Shumei Wang
d)
2
School of Food Science and Engineering, Harbin Institute of Technology
, Harbin 150000, China
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a)Corresponding author email: 873790844@qq.com
AIP Conf. Proc. 2208, 020025 (2020)
Citation
Chaohui Xue, Le Yuan, Hongbo Li, Shumei Wang; S-layer proteins from lactobacillus paracasei M7 mediated inhibition of Salmonella-induced apoptosis. AIP Conf. Proc. 19 February 2020; 2208 (1): 020025. https://doi.org/10.1063/5.0000026
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