Glucosamine or 2-amino-2-deoxy-D-glucose is a natural monosaccharide. Glucosamine has been used extensively in the fields of nutrition, pharmacy, and cosmetics. Usually, glucosamine is obtained by complete hydrolysis of chitin using strong mineral acid at high temperature. Although acid hydrolysis has several disadvantages as caramel formation and low selectivity, this method is still interesting because it is simple and easy. Recently, microwave irradiation has been widely used in organic chemical reactions because of its ability to reduce both energy consumption and reaction time. In this study, preparation of glucosamine by acid hydrolysis of chitin using irradiation microwave was compared to conventional heating. The result showed that using conventional heating with hydrochloric acid 8 N, 95°Cof temperature process, ratio of chitin and HCl in 1:4 (w/v), and reaction time of 120 minutes yielded 58.8%. Whilst chitin hydrolysis using microwave irradiation with the power of 400 watts and for 25 minutes of reaction time yielded 67.1%. FTIR analysis showed that the glucosamine product from chitin hydrolysis using both conventional heating and microwave irradiation have similar structure with standard glucosamine. Glucosamine from Merck with the purity of 99% was used as the standard.
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2 January 2020
PROCEEDINGS OF 2ND INTERNATIONAL CONFERENCE ON CHEMICAL PROCESS AND PRODUCT ENGINEERING (ICCPPE) 2019
25–26 September 2019
Semarang, Indonesia
Research Article|
January 02 2020
Preparation of glucosamine by acid hydrolysis of chitin under microwave irradiation
Nur Rokhati;
Nur Rokhati
a)
1
Membrane Research Center (MeR-C), Integrated Laboratory for Research and Services,Diponegoro University
, Semarang, Indonesia
2
Department of Chemical Engineering, Faculty of Engineering, Diponegoro University
, Semarang, Indonesia
a)Corresponding author: [email protected]
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Tutuk D. Kusworo;
Tutuk D. Kusworo
b)
2
Department of Chemical Engineering, Faculty of Engineering, Diponegoro University
, Semarang, Indonesia
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Heru Susanto;
Heru Susanto
c)
1
Membrane Research Center (MeR-C), Integrated Laboratory for Research and Services,Diponegoro University
, Semarang, Indonesia
2
Department of Chemical Engineering, Faculty of Engineering, Diponegoro University
, Semarang, Indonesia
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I. Nyoman Widiasa;
I. Nyoman Widiasa
d)
2
Department of Chemical Engineering, Faculty of Engineering, Diponegoro University
, Semarang, Indonesia
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Nita Aryanti;
Nita Aryanti
e)
2
Department of Chemical Engineering, Faculty of Engineering, Diponegoro University
, Semarang, Indonesia
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Arlunanda Adhiartha;
Arlunanda Adhiartha
f)
1
Membrane Research Center (MeR-C), Integrated Laboratory for Research and Services,Diponegoro University
, Semarang, Indonesia
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Yunita Fahni;
Yunita Fahni
g)
1
Membrane Research Center (MeR-C), Integrated Laboratory for Research and Services,Diponegoro University
, Semarang, Indonesia
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Nur ‘Aini Hamada
Nur ‘Aini Hamada
h)
1
Membrane Research Center (MeR-C), Integrated Laboratory for Research and Services,Diponegoro University
, Semarang, Indonesia
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Nur Rokhati
1,2,a)
Tutuk D. Kusworo
2,b)
Heru Susanto
1,2,c)
I. Nyoman Widiasa
2,d)
Nita Aryanti
2,e)
Arlunanda Adhiartha
1,f)
Yunita Fahni
1,g)
Nur ‘Aini Hamada
1,h)
1
Membrane Research Center (MeR-C), Integrated Laboratory for Research and Services,Diponegoro University
, Semarang, Indonesia
2
Department of Chemical Engineering, Faculty of Engineering, Diponegoro University
, Semarang, Indonesia
AIP Conf. Proc. 2197, 070001 (2020)
Citation
Nur Rokhati, Tutuk D. Kusworo, Heru Susanto, I. Nyoman Widiasa, Nita Aryanti, Arlunanda Adhiartha, Yunita Fahni, Nur ‘Aini Hamada; Preparation of glucosamine by acid hydrolysis of chitin under microwave irradiation. AIP Conf. Proc. 2 January 2020; 2197 (1): 070001. https://doi.org/10.1063/1.5140934
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