Ozone is a gas that naturally exists in the Earth’s atmosphere, has a strong odor, strong oxidizer, and as a disinfecting agent. Determination of the ozone concentration produced by the reactor is very important. Development of a reactor for lower concentrations of ozone needs to be done. The reactor type can use for medical ozone therapy applications. Medical ozone therapy can be produced using multiple DBD plasma reactors with oxygen as a source and voltage variation. The voltage source uses high voltage AC with variations between 0.5-3 kV, a frequency of 40 Hz and measurement of the concentration of titration of ozone production carried out for 2 minutes. The reactor formed by the configuration of copper spiral mesh electrodes with variations in the number of turns 50 and 30 applied to spiral electrodes and the length of the mesh electrodes 13 and 9 cm. Pure oxygen put into the reactor with several variations in the flow rate of 0.2-1 L/min. The titration method is a high-accuracy analytical chemical method that still used. The results showed that the greater the gas flow rate, the lower the ozone concentration produced, the higher the flow rate the dose value was 595.2 mg and 499.2 mg with a voltage of 3 kV, while the low flow rate was 220, 8 mg and 326.4 mg but the number of turns and mesh length also affects the concentration and dosage value, in windings of 50 and the mesh length of 13 cm the concentration are greater than those in coil 30 and mesh length 9 cm.

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