Diet is an important factor in the control and improvement of various psychological problems such as depression, anxiety, hyperactivity and behavioral impulsivity. Anorexia Nervosa (AN) is a psychological problem that occurs most commonly in adolescent females although men are also susceptible. The patients exhibit self-imposed, reduced body weight, anxiety, hyperactivity and behavioral impulsivity. The involvement of 5-hydroxytryptamine (5-HT) in the regulation of hunger and mood is well documented. Studies have shown that the hyperactivity elicited by diet restrictions (DR) could result from increased sensitization of somatodendritic 5-HT1Aautoreceptors, thus leading to a decreased brain serotonin turnover. Fluoxetine; a Selective Serotonin Reuptake Inhibitor (SSRI) is, generally, used as an antidepressant. Fluoxetine increases extracellular serotonin levels by inhibiting its reuptake from the synaptic cleft and later by desensitization of 5-HT-1A somatodendritic autoreceptors in the brain. The present experiment is designed to monitor the effects of fluoxetine administration to desensitized 5-HT1A receptors that may increase serotonin concentration in DR rats. Results may be helpful to inhibit behavioral deficits induced by diet-restriction-induced AN in rats. Methods: Fluoxetine at low dose and high dose was given orally to respective freely fed or diet restricted animals daily for five weeks. Behavioral activities were also monitored weekly. Results: Fluoxetine (at a low dose and high dose) increased significantly food intake and body weight in diet restricted rats. Fluoxetine also produced anxiolytic-like effects in DR rats measured as decreased activity in the open field and increased time spent in the light compartment. This might be associated with increased serum tryptophan and brain serotonin metabolism. Conclusion: It is concluded that the Pharmacological agents which increased serotonin availability or desensitizing 5-HT1A receptors are likely to improve behavioral deficits and psychological problems associated with anorexia nervosa.
Skip Nav Destination
Article navigation
19 August 2019
INTERNATIONAL CONFERENCE ON KEY ENABLING TECHNOLOGIES (KEYTECH 2019)
24–26 April 2019
Istanbul, Turkey
Research Article|
August 19 2019
Pharmacotherapy of diet-restriction-induced-anorexia nervosa with fluoxetine in rats
Darakhshan M. Saleem;
Darakhshan M. Saleem
a)
1
Biomedical Engineering Department, Neural Science and Neural engineering research unit Sir Syed University of Engineering & Technology
, Karachi, Karachi, Pakistan
a)Corresponding Author:[email protected]
Search for other works by this author on:
Zohra Jabeen;
Zohra Jabeen
1
Biomedical Engineering Department, Neural Science and Neural engineering research unit Sir Syed University of Engineering & Technology
, Karachi, Karachi, Pakistan
Search for other works by this author on:
Darakhshan J. Haleem
Darakhshan J. Haleem
2
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi
, Pakistan
Search for other works by this author on:
a)Corresponding Author:[email protected]
AIP Conf. Proc. 2146, 020014 (2019)
Citation
Darakhshan M. Saleem, Zohra Jabeen, Darakhshan J. Haleem; Pharmacotherapy of diet-restriction-induced-anorexia nervosa with fluoxetine in rats. AIP Conf. Proc. 19 August 2019; 2146 (1): 020014. https://doi.org/10.1063/1.5123701
Download citation file:
Pay-Per-View Access
$40.00
Sign In
You could not be signed in. Please check your credentials and make sure you have an active account and try again.
41
Views
Citing articles via
Inkjet- and flextrail-printing of silicon polymer-based inks for local passivating contacts
Zohreh Kiaee, Andreas Lösel, et al.
Effect of coupling agent type on the self-cleaning and anti-reflective behaviour of advance nanocoating for PV panels application
Taha Tareq Mohammed, Hadia Kadhim Judran, et al.
Design of a 100 MW solar power plant on wetland in Bangladesh
Apu Kowsar, Sumon Chandra Debnath, et al.
Related Content
Modified student teams-achievement divisions (STAD) with case-based learning to improve the quality of respiratory and gastrointestinal pharmacotherapy course
AIP Conf. Proc. (October 2018)
Diet sago (Metroxylon sago Rottb.) on hemoglobin level of young mice (Mus musculus) with hyperbilirubinemia from female parents gestasional diabetes mellitus
AIP Conf. Proc. (January 2023)
Studies on iridovirus infection among grouper fish (Epinephelus sp.) cultured in Seribu Islands, Indonesia
AIP Conf. Proc. (April 2019)
A diet recommendation for diabetic patients using integer programming
AIP Conf. Proc. (August 2019)