Objective: To analyze the clinical efficacy of thoracic laparoscopic combined radical surgery in elderly patients with esophageal cancer and its effect on immune function. Methods: From December 2013 to January 2018, 92 elderly patients with esophageal cancer admitted to our hospital were randomly divided into two groups. Patients treated with conventional esophageal cancer radical surgery were classified as the control group (n=46). Patients treated with laparoscopic radical operation were classified as observation group (n=46), and the changes of surgical indexes, recurrence and immune function indexes were compared between the two groups. Results: 1 year after operation, the recurrence rate of the observation group was 23.91% (11/46), which was lower than that of the control group (85.96% (40/46). The difference between the groups was obvious, X2=37.0024, P<0.05; except for lymph node dissection. In addition, the other surgical indexes of the observation group were better than the control group, and the difference between the groups was significant (P<0.05). The levels of NK cells, CD4+/CD8+ and CD4+ cells in the observation group were higher than those in the control group. t=12.6325, 10.2362, 8.9626, P<0.05. Conclusion: The clinical efficacy of thoracic laparoscopic combined with radical surgery in elderly patients with esophageal cancer is significant, which can effectively improve the immunosuppressive state and reduce the recurrence rate.

Topics
Diseases and conditions, Organs
1.
Gao
 
Yunfei
,
Luo
 
Dongbo
, et al. 
Serum Levels of Inflammatory Factors, Lung Function and Prognosis in Patients with Esophageal Cancer After Endoscopy-assisted Radical Esophagectomy
[J].
Journal of Chinese Oncology
,
2018
,
24
(
1
):
42
–
46
.
Google Scholar
 
2.
She
 
Xiaowei
,
Zhao
 
Jun
, et al. 
Clinical Comparison of Minimally Invasive Esophagectomy Versus Open Esophagectomy on Elderly Esophageal Carcinoma Patients (≥70 Years Old
) [J].
Cancer Research on Prevention and Treatment
,
2017
,
44
(
11
):
740
–
744
.
Google Scholar
 
3.
Zhang
 
Xiaobin
,
Yang
 
Yu
, et al. 
Efficacy Analysis of Da Vinci Robot-assisted Esophagectmy and Combined Thoracoscopy-and Laparoscopy-assisted Esophagectomy [J]
.
Chinese Journal of Digestive Surgery
,
2017
,
16
(
8
):
844
–
849
.
Google Scholar
 
4.
Sun
 
Yongpan
,
Mei
 
Hong
, et al. 
Feasibility, Safety and Short-term Efficacy of Thoracoscopy and Laparoscopy Combined with Ivor-Lewis Surgery for Middle and Lower Esophageal Carcinoma [J]
.
Hainan Medical Journal
,
2017
,
28
(
4
):
575
–
577
.
Google Scholar
 
5.
Wan
 
Jun
,
Kang
 
Ningning
, et al. 
Surgical Methods, Safety and Clinical Effect of Thoracolaparoscopy Three-field Esophagectomy in Treatment of Esophageal Cancer
[J].
Anhui Medical Journal
,
2016
,
37
(
6
):
649
–
652
.
Google Scholar
 
6.
Cui
 
Wenfeng
,
Cao
 
Jiwei
,
Ba
 
Yufeng
.
The Impact of Thoracoscope Laparoscopic Radical Prostatectomy on Pulmonary Function and Inflammatory Factor in Elderly Patients with Esophageal Cancer
[J].
Journal of Chinese Oncology
,
2017
,
23
(
9
):
823
–
826
.
Google Scholar
 
7.
Yan
 
Jin
,
Li
 
Qinghua
, et al. 
The Clinical Curative Effect of Combined Thoracoscopic and Laparoscopic Surgery for Esophageal Cancer and the Effect on Serum C-reactive Protein and Coagulation
[J].
Oncology Progress
,
2017
,
15
(
1
):
66
–
68
.
Google Scholar
 
8.
Wang
 
Chuangfang
,
Jiang
 
Feng
, et al. 
Clinical Curative Effect of Thoracic Laparoscopic Combined Radical Treatment for Elderly Patients with Esophageal Cancer and Its Effects on the Immune Function
[J].
Journal of Clinical and Experimental Medicine
,
2017
,
18
(
3
):
277
–
280
.
Google Scholar
 
This content is only available via PDF.
© 2019 Author(s).
2019
Author(s)
You do not currently have access to this content.