Introduction: Garlic (Allium sativum) has been used for a long time as a spice or traditional medicine. Garlic contains allicin compound which has the role as anti-infective agents. This study aims to determine the potential of garlic as an antimicrobial agent in Staphylococcus aureus and Corynebacterium diphtheriae bacteria in vitro and determine the activity of allicin as an antibacterial in silico. Method: This study used garlic extract with the aqueous extract method. The antimicrobial potential test used in this study was the Kirby-Bauer disk diffusion test. The activity of allicin compounds as antibacterial agents was explored through in silico analysis using molecular docking methods to target proteins that play a role in bacterial division (FtsZ protein) with Autodock Vina. Results: The results showed that there were significant differences in the size of the inhibitory zone of garlic extract (Allium sativum) on the growth of Staphylococcus aureus bacteria (p <0.05) and Corynebacterium diphtheriae (p <0.05). The results of in silico analysis of allicin compounds showed significant inhibitory activity on the FtsZ protein compared to penicillin, with an affinity of -10 kcal/mol. Conclusion: The results of this study indicate that garlic extract (Allium sativum) shows antibacterial potential in vitro. In addition, allicin compounds contained in garlic extract have the potential as one of the alternative targets for new antibiotics.
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4 June 2019
INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND NANO-MEDICINE FROM NATURAL RESOURCES FOR BIOMEDICAL RESEARCH: 3rd Annual Scientific Meeting for Biomedical Sciences
21–23 November 2018
Malang, Indonesia
Research Article|
June 04 2019
Antibacterial activity of garlic (Allium sativum) extract and molecular docking studies of allicin
Wike Astrid Cahayani;
Wike Astrid Cahayani
a)
1
Laboratory of Anatomy and Histology, Faculty of Medicine, Universitas Brawijaya
, Indonesia
a)Corresponding author: cahayani.wa@ub.ac.id
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Calvin Tanuwijaya;
Calvin Tanuwijaya
2
Graduate student of Faculty of Medicine, Universitas Brawijaya
, Indonesia
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Lum Xiao Chi;
Lum Xiao Chi
2
Graduate student of Faculty of Medicine, Universitas Brawijaya
, Indonesia
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Yuanita Mulyastuti
Yuanita Mulyastuti
3
Laboratory of Microbiology, Faculty of Medicine, Universitas Brawijaya
, Indonesia
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a)Corresponding author: cahayani.wa@ub.ac.id
AIP Conf. Proc. 2108, 020045 (2019)
Citation
Wike Astrid Cahayani, Calvin Tanuwijaya, Lum Xiao Chi, Yuanita Mulyastuti; Antibacterial activity of garlic (Allium sativum) extract and molecular docking studies of allicin. AIP Conf. Proc. 4 June 2019; 2108 (1): 020045. https://doi.org/10.1063/1.5110020
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