Increased oxidative stress can underlie the occurrence of cerebrovascular disease, including hypertension, atherosclerosis, vascular endothelial dysfunction, and ischemic heart disease. Black garlic is a clove of fresh garlic that is fermented at high temperatures to produce a lot of antioxidants. The high content of organosulfur compounds can act as antioxidants to reduce atherosclerosis, as an anti-inflammatory to reduce endothelial cell damage, prevent oxidized LDL-c, strengthen endogenous antioxidant enzymes, increase HDL-c, reduce vascular resistance, reduce LDL-c, TG and total cholesterol. The underlying mechanism further clarifies the function of black garlic as an anti-atherosclerotic to prevent cardiovascular disease.

1.
H J
Hussein
,
I H
Hameed
, and
M Y
Hadi
Res. J. Pharm. Tech
10
4069
(
2017
).
2.
I S
Choi
,
H S
Cha
, and
Y S
Lee
Molecules
19
16811
(
2014
).
3.
D
Wang
,
Y
Feng
,
J
Liu
,
J
Yan
,
M
Wang
,
J
Sasaki
, and
C
Lu
Med. Aromat. Plant Sci. Biotechnol.
4
37
(
2010
).
4.
K
Ried
and
P
Fakler
Integr. Blood Press. Control
7
71
(
2014
).
5.
S
Inam
,
F
Javed
,
F
Rasheed
, and
A
Hannan
Ann. Pak. Inst. Med. Sci.
111
(
2018
).
6.
J H
Ryu
and
D
Kang
Molecules
22
(
2017
).
7.
A
Pircher
,
L
Treps
,
N
Bodrug
, and
P
Carmeliet
Atherosclerosis
1
(
2016
).
8.
A E
Morgan
,
K M
Mooney
,
S J
Wilkinson
,
N A
Pickles
, and
M T M
Auley
Ageing Res. Rev.
27
108
(
2016
).
9.
C
Barale
,
C
Frascaroli
,
R
Senkeev
,
F
Cavalot
, and
I
Russo
Biomed Res. Int.
2018
1
(
2018
).
10.
N A
Golubkina
,
T M
Seredin
,
O V
Kosheleva
, and
A V
Soldatenko
Микроэлементы В Медицине
18
3
(
2017
).
11.
X
Lu
,
N
Li
,
X
Qiao
,
Z
Qiu
, and
P
Liu
J. Food Drug Anal.
25
340
(
2017
).
12.
S
Hayat
,
Z
Cheng
,
H
Ahmad
,
M
Ali
,
X
Chen
, and
M
Wang
Front. Plant Sci.
7
1
(
2016
).
13.
S
Saryono
and
A
Proverawati
Transylvanian Rev.
26
7649
(
2018
).
14.
S
Saryono
,
J
Eliyan
,
D
Herdiati
,
A
Khikmatullah
,
C
Silvana
, and
H
Adi
IOP Conf. Ser. Mater. Sci. Eng.
172
(
2017
).
15.
Y Y
Jeong
,
J H
Ryu
,
J
Shin
,
M J
Kang
, and
J R
Kang
Molecules
21
1
(
2016
).
16.
W
Wang
and
Y
Sun
Food Sci. Technol, Campinas
37
681
(
2017
).
17.
A Y
Nasr
Toxicol. Reports
1
682
(
2014
).
18.
E-S
Jung
,
S-H
Park
,
E-K
Choi
,
B-H
Ryu
,
B-H
Park
,
D-S
Kim
,
Y-G
Kim
, and
S-W
Chae
Nutrition
1034
(
2014
).
19.
Tran Gia
Buu
,
D S
Mai
, and
L N T
Tram
Int. J. Hepatol.
1
(
2018
).
20.
A W
Ha
,
T
Ying
, and
W K
Kim
Nutr. Res. Pract.
9
30
(
2015
).
21.
R K
Upadhyay
Int. J. Green Pharm.
10
S1
(
2016
).
22.
Y
Sun
,
W
Wang
, and
J
Qin
Medicine (Baltimore).
97
1
(
2018
).
23.
T W
Lee
,
E
Bae
,
J H
Kim
,
H N
Jang
,
H S
Cho
, and
D J
Park
Ren. Fail.
41
24
(
2019
).
24.
I
Pérez-torres
,
J C
Torres-narváez
,
J
Pedraza-chaverri
,
M E
Rubio-ruiz
,
E
Díaz-díaz
,
L
Valle-mondragón
,
R
Martínez-memije
,
E V
López
, and
V
Guarner-lans
Molecules
21
1
(
2016
).
25.
S
Amor
,
D
Gonz
,
B
Mart
,
A
Manuel
,
P
Almod
,
M
Prodanov
,
A
Luis
, and
M
Granado
Nutrients
11
1
(
2019
).
26.
J
Liu
,
G
Zhang
,
X
Cong
, and
C
Wen
Front. Physiol.
9
1
(
2018
).
27.
A
Czompa
,
K
Szoke
,
J
Prokisch
,
A
Gyongyosi
,
I
Bak
,
G
Balla
,
A
Tosaki
, and
I
Lekli
Int. J. Mol. Sci.
19
1017
(
2018
).
28.
N M
El-Beih
,
G
Ramadan
,
M A
Khorshed
, and
R S A
Ahmed
Indian J. Tradit. Knowl.
16
181
(
2017
).
29.
D Y
Seo
,
S
Lee
,
A
Figueroa
,
Y S
Kwak
,
N
Kim
,
B D
Rhee
,
K S
Ko
,
H S
Bang
,
Y H
Baek
, and
J
Han
Nutr Res Pr.
6
513
(
2012
).
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