Banana peel is a potential natural source of serotonin precursor, which contains 5-hydroxytryptophan (5-HTP), tryptophan, and some other nutrients needed in serotonin metabolism. Serotonin is a neurotransmitter, which has a role in gastrointestinal motility and may affect stool consistency. The effect of banana peel extract on serotonin immunoreactivity and stool consistency is yet unclear. Here we aimed to investigate the effect of banana peel extract on serotonin immunoreactivity and stool consistency in the male. Twenty-five male Wistar rats (8-10 weeks old), were divided into 5 groups: Control Group (C), a control positive 5-HTP group given 5-HTP 1.50 mg/Kg, Banana Peel Extract Group dose 4 mg/KgBW (T1), Banana Peel Extract Group dose 8 mg/Kg (T2) and Banana Peel Extract Group dose 16 mg/Kg (T3). Stool consistency score was measured to examine stool consistency. Immunohistochemistry staining was measured to examine serotonin immunoreactivity. Oral administration of banana peel extract in T3 group (307.3±69.2) group resulted in the enhancement of serotonin immunoreactivity (p<0.05) compared to the control group (199.9±20.7). Stool consistency score of T1, T2, and T3 groups showed no difference compared to control and positive control groups. These results suggest that the administration of banana peel extract 16 mg/Kg increase serotonin immunoreactivity in male Wistar rat, but it is not related to stool consistency.

1.
K.M.
Sanders
,
S.D.
Koh
,
S.
Ro
, and
S.M.
Ward
,
Nat Rev Gastroenterol Hepatol.
9
(
11
),
633
45
(
2012
)
2.
M.I.P
Sanchez
, and
P.
Bercik
,
Can J Gastroenterol.
25
Suppl B
,
11B
15B
(
2011
)
3.
A.
Fujitani
,
T.
Sogo
,
A.
Inui
, and
K.
Kawakubo
,
Gastroenterol Res Pract.
2018
,
1
8
(
2018
)
4.
S.J.
Lewis
, and
K.W.
Heaton
,
Scand J Gastroenterol
,
32
(
9
),
920
4
(
1997
)
5.
J.
Tinmouth
,
G.
Tomlinson
,
G.
Kandel
,
S.
Walmsley
,
H.A.
Steinhart
, and
R.
Glazier
,
HIV Clin Trials.
8
(
6
),
421
8
(
2007
)
6.
P.J.
O’Connell
,
X.
Wang
,
M.
Leon-Ponte
,
C.
Griffiths
,
S.C.
Pingle
, and
G.P.
Ahern
,
Blood
,
107
(
3
),
1010
7
(
2005
)
7.
M.B.
Hansen
,
F.
Arif
,
H.
Gregersen
,
H.
Bruusgaard
, and
L.
Wallin
,
Physiol Res
,
57
(
1
),
63
71
(
2008
)
8.
G.M.
Mawe
,
M.D.
Coates
, and
P.L.
Moses
,
Aliment Pharmacol Ther.
23
(
8
):
1067
76
(
2006
)
9.
M.D.
Crowell
,
Br J Pharmacol
,
141
(
8
),
1285
93
(
2004
)
10.
M.
Hagbom
,
C.
Istrate
,
D.
Engblom
,
T.
Karlsson
,
J.
Rodriguez-Diaz
,
J.
Buesa
, et al,
PLoS Pathog
,
7
(
7
),
1
10
(
2011
)
11.
J.
Mazières
,
W.
Brugger
,
F.
Cappuzzo
,
P.
Middel
,
A.
Frosch
,
I.
Bara
, et al,
Lung Cancer
,
82
:
231
7
(
2013
)
12.
C.P.
Lynn-Bullock
,
K.
Welshhans
,
S.L.
Pallas
, and
P.S.
Katz
,
J Chem Neuroanat
27
(
2
),
129
38
(
2004
)
13.
M.H.
Baumann
,
Z.
Williams
,
D.
Zolkowska
, and
R.B.
Rothman
,
Drug Alcohol Depend
114
(
2–3
),
147
52
(
2011
)
14.
D.
Hranilovic
,
S.
Blazevic
,
N.
Ivica
,
L.
Cicin-Sain
, and
D.
Oreskovic
.
Neurochem Int
59
(
2
):
202
7
(
2011
)
15.
A.
Amer
,
J.
Breu
,
J.
McDermott
,
R.J.
Wurtman
, and
T.J.
Maher
,
Pharmacol Biochem Behav
77
(
1
),
137
43
(
2004
)
16.
A.
Moshfegh
,
J.
Goldman
,
J.
Ahuja
,
D.
Rhodes
, and
R.
LaComb
,
US Dep Agric Agric Res Serv
(
2009
)
17.
T.H.
Emaga
,
R.H.
Andrianaivo
,
B.
Wathelet
,
J.T.
Tchango
, and
M.
Paquot
M, Food Chem.
103
(
2
),
590
600
(
2007
)
18.
A.
Mesripour
,
V.
Hajhashemi
, and
A.
Kuchak
,
Res Pharm Sci
12
(
1
),
46
52
(
2017
)
19.
V.
Pokkunuri
,
M.
Pimentel
,
W.
Morales
,
S.R.
Jee
,
J.
Alpern
,
S.
Weitsman
, et al,
J Neurogastroenterol Motil
18
(
4
),
434
42
(
2012
)
20.
F.D.M.
Feijó
,
M.C.
Bertoluci
, and
C.
Reis
,
Rev Assoc Med Bras
57
(
1
),
74
7
(
2010
)
21.
M.
Berger
,
J.A.
Gray
, and
B.L.
Roth
,
Annu Rev Med
60
(
1
),
355
66
(
2009
)
22.
K.
Sjölund
,
G.
Sandén
,
R.
Håkanson
, and
F.
Sundler
,
Gastroenterology
85
(
5
),
1120
30
(
1983
)
23.
J.
Wheatcroft
,
D.
Wakelin
,
A.
Smith
,
C.R.
Mahoney
,
G.
Mawe
, and
R.
Spiller
,
Neurogastroenterol Motil.
17
(
6
),
863
70
(
2005
)
24.
J.
Kałużna-Czaplińska
,
J.
Jóźwik-Pruska
,
S.
Chirumbolo
, and
G.
Bjørklund
,
Metab Brain Dis.
32
(
5
),
1585
93
(
2017
)
25.
P.P.
Bertrand
, and
R.L.
Bertrand
,
Auton Neurosci
153
(
1–2
),
47
57
(
2010
)
26.
D.R.
Jacobs
,
M.D.
Gross
, and
L.C.
Tapsell
,
Am J Clin Nutr
89
(
5
),
1543
8
(
2009
)
27.
M.D.
Gershon
, and
J.
Tack
,
Gastroenterology
132
(
1
),
397
414
(
2007
)
This content is only available via PDF.
You do not currently have access to this content.