Surface electrical charge had been a key factor for the functional activity of synaptosomes induced by neurotransmitters treatment. The interaction of L-glutamic acid, gamma-aminobutyric acid and kainic acid with the interface of synaptosomal membrane was investigated. According to our knowledge, so far there were no reports on a characterization of surface properties and aggregate’s formation of synaptosomal membranes using microelectrophoresis and 90o light scattering techniques. It was found that the upper neurotransmitters altered the surface and light scattering properties of synaptosomes during in vitro aging of the membrane after 1st, 2nd and 3rd day after isolation of rat brain synaptosomal membranes.
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