Investigation of flexible polyelectrolyte multilayered structure by using different techniques

The presented paper deals with the formulation of medical pads with potential use as drug delivery systems via buccal mucosa adhesion. The pads consists of a substrate and deposited on it multilayered structure of alternating casein and chitosan. The method of preparation of this multilayer structure is layer-by-layer deposition. The electrolyte nature of the used polymers (chitosan – polyanion and casein – polycation) was employed in the formulation process. The substrate initial excess charge was provided by corona discharge pretreatment. The formulation process was monitored by index of refraction measurements by using a laser refractometer. The ability of the formulated pads as drug delivery system was proven by drug release tests, where the kinetics of benzydamine hydrochloride (BH) was used. The method of mucin reaction was employed to establish the potential of pads‘ adhesion.