A novel 2-Butyl-4-chloro-5-formylimidazole thiosemicarbazonecobalt (II) complex is synthesized and characterized by using spectroscopic techniques like elemental analysis, FT-IR, HRMS, electronic spectral analysis and Powder-X-ray diffraction. The Co(II) complex is found to be highly efficient in inhibiting the growth of human pathogens likeS. aureusand B. megaterium with MIC value 12.0 µg/mL whose inhibition zones are almost comparable with the standard antibiotic. The synthesized complex well occupies in the active site of β- ketoacyl-acyl carrier protein synthase III enzyme (PDB: 1MZS), in consists of catalytic triad and adenine-binding site, so the designed compoundis promising for to treat bacterial infection.
Synthesis, spectroscopic characterization and molecular docking studies of 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone cobalt(II) complex
A. Sreenath Reddy, L. Sivarama Krishna, Vishnu Nayak Badavath, G. Sravya, N. Bakthavatchala Reddy, Grigory V. Zyryanov; Synthesis, spectroscopic characterization and molecular docking studies of 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone cobalt(II) complex. AIP Conf. Proc. 11 January 2019; 2063 (1): 040054. https://doi.org/10.1063/1.5087386
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