Synthesis of azaheterocyclic derivatives of 5,7-dimethoxycoumarins by CH/CH functionalization with quinazolines

A new approach was developed for nucleophilic substitution of hydrogen in quinazoline derivatives under the action of 5,7-dimethoxycoumarins. Such reactions provide direct synthetic route avoiding pre-functionalization of the C–H bond. The advantages of this environmentally benign approach are high regio- and chemoselectivity, and an easy workup procedure.