Synthesis of a new class of heteroaryl dipyrazolyl carbothioamides and heteroaryl dipyrazolyl thiazoles and evaluation as antioxidants

A new class of indolyl dipyrazoles and indolyl dipyrazolyl thiazoles were prepared from the Michael acceptor (E)-3-(1H-indol-3-yl)-1-(4-aryl-1H-pyrazol-3-yl)prop-2-en-1-one under ultrasonication. All the compounds were obtained in higher yields and in shorter reaction times under ultrasound irradiation method. The lead compounds were tested for antioxidant activity. Amongst all the tested compounds methoxy substituted indolyl dipyrazolyl thiazole displayed pronounced antioxidant activity.