Quaternary ammonium derivatives of 2-aminothiophene-3-carboxylates with antimicrobial activity

Reaction of alkyl chlorides and N-benzylimidazole was conducted by refluxing them in dioxane. The synthesized product was characterized using ¹H-NMR. The reaction yielded white solid quaternary ammonium salts (QAS) in 31-82%. QAS have been widely researched its activity as antimicrobial and antibacterial. The substitution of the functional groups on the QAS structure affects its biological activity. Antimicrobial activity of QAS was assayed by the method of serial twofold dilutions in a liquid nutrient medium. According to the results, QAS could potentially be developed as a new drug candidate for the treatment of microbial infections.