Operationally simple and convenient synthesis of selectively protected derivatives of 5,7-dihydroxycoumarins was proposed. The proposed method is based on the reaction of the coumarins with nicotinoyl azide yielding 7-nicotinoyloxy derivatives of the coumarins. This approach can significantly improve the procedure for preparing the dimethylpyranocoumarins, an important semiproduct for synthesis of anti-HIV agents.
New approach to the synthesis of biologically active derivatives of pyranocoumarins
A. K. Inyutina, R. F. Fatykhov, I. A. Khalymbadzha, A. D. Sharapov, M. V. Bobkina, O. N. Chupakhin; New approach to the synthesis of biologically active derivatives of pyranocoumarins. AIP Conf. Proc. 11 January 2019; 2063 (1): 040019. https://doi.org/10.1063/1.5087351
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