A highly expedient protocol for a catalytic Appel-type dehydration of oximes to nitriles has been developed, which employs oxalyl chloride, triethylamine and triphenylphosphine oxide as a catalyst. The reactions are usually complete in less than 10 min with only 1 mol % of catalysts loading.
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Research Article| January 11 2019
Dehydration of oxime to nitriles
S. A. Shipilovskikh;
S. A. Shipilovskikh a)
Department of Chemistry Perm State University, Bukireva 15, Perm 614990,
Institute of Chemical Technology, Ural Federal University, Mira 19, Yekaterinburg, 620002,
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AIP Conf. Proc. 2063, 030019 (2019)
S. A. Shipilovskikh, A. E. Rubtsov; Dehydration of oxime to nitriles. AIP Conf. Proc. 11 January 2019; 2063 (1): 030019. https://doi.org/10.1063/1.5087327
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