Polyvinyl alcohol (PVA) hydrogels have desirable characteristics for use as a soft tissue substitute. However, their low mechanical strength and biocompatibility hinder the wide range of biomedical application. Herein, hydroxyapatite blended PVA/HAp composite hydrogel was developed by freeze-thawing and annealing method. The microstructure and rheological properties such as storage and loss modulus are investigated. Samples showed a porous structure with interconnected porosity and HAp distributed uniformly in a PVA matrix. Further, the composite hydrogel showed favorable viscoelastic properties and is suitable for artificial articular cartilage replacement.
Viscoelastic behavior of HAp reinforced polyvinyl alcohol composite hydrogel for tissue engineered articular cartilages
B. Y. Santosh Kumar, Arun M. Isloor, G. C. Mohan Kumar; Viscoelastic behavior of HAp reinforced polyvinyl alcohol composite hydrogel for tissue engineered articular cartilages. AIP Conf. Proc. 11 January 2019; 2057 (1): 020062. https://doi.org/10.1063/1.5085633
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