Cyclization reaction of dimethoxychalcone and hydrazine was conducted by refluxing them for 6 h in glacial acetic acid. The synthesized product was characterized using 1H-NMR, FT-IR and GC-Mass spectrometers. The reaction yielded red solid pyrazoline in 53.80%. The 1H-NMR spectra showed proton peaks in upfield shift that identified as proton’s signal of pyrazoline ring. In addition, the presence of proton peak of hydrazone showed that the reaction is predicted through 1,3-dipolar cycloaddition reaction. Pyrazoline that has been synthesized, have antibacterial activity against positive and negative bacteria. However, its activity was not good and need to be further studied.

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