Tempe is a functional food prepared from soybeans through Rhizopus spp. fermentation, originated from Indonesia. The present study was performed to investigate the cytotoxicity and antioxidant activity of tempe prepared from fermentation for 0-156 h and extracted with ethanol. The cytotoxicity was assessed on MCF 7 breast cancer cells using alamarBlue™ method. The antioxidant activity determined by DPPH free radical scavenging assay. The results indicated that ethanol extracts of 108 h tempe showed cytotoxicity potency at IC50 5.20 ± 1.01 μg/mL against MCF-7 breast cancer cell. Ethanol extract of 120 h tempe showed the highest antioxidant activity expressed as percent of inhibition, with no significant difference to those of 108 h tempe. It can be concluded that the cytotoxicity of tempe from 0-156 h of fermentation is correlated to their corresponding antioxidant activtity. Longer fermentation time, up to 108 h, increased the ability of tempe to inhibit the growth of the oxidative reaction and growth of MCF-7 breast cancer cells. Extended fermentation time, up to 156 h, tends to decrease the abilities of cytotoxicity and antioxidant activity.
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7 November 2018
PROCEEDINGS OF THE 4TH INTERNATIONAL SYMPOSIUM ON APPLIED CHEMISTRY 2018
1–2 November 2018
Banten, Indonesia
Research Article|
November 07 2018
Cytotoxicity of ethanol overripe tempe extract against MCF-7 breast cancer cell and its antioxidant activity
Dian Muzdalifah;
Dian Muzdalifah
a
Research Centre for Chemistry, Indonesia Institute of Sciences
, Kawasan PUSPIPTEK Serpong, South Tangerang, Banten, Indonesia
, 15314
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Zatil Afrah Athaillah;
Zatil Afrah Athaillah
Research Centre for Chemistry, Indonesia Institute of Sciences
, Kawasan PUSPIPTEK Serpong, South Tangerang, Banten, Indonesia
, 15314
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Anastasia F. Devi;
Anastasia F. Devi
Research Centre for Chemistry, Indonesia Institute of Sciences
, Kawasan PUSPIPTEK Serpong, South Tangerang, Banten, Indonesia
, 15314
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Linar Z. Udin
Linar Z. Udin
Research Centre for Chemistry, Indonesia Institute of Sciences
, Kawasan PUSPIPTEK Serpong, South Tangerang, Banten, Indonesia
, 15314
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AIP Conf. Proc. 2024, 020037 (2018)
Citation
Dian Muzdalifah, Zatil Afrah Athaillah, Anastasia F. Devi, Linar Z. Udin; Cytotoxicity of ethanol overripe tempe extract against MCF-7 breast cancer cell and its antioxidant activity. AIP Conf. Proc. 7 November 2018; 2024 (1): 020037. https://doi.org/10.1063/1.5064323
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