The application of biodegradable synthetic polymers become centre of attraction as the versatility structure of polymer itself fascinating with the fact that it can be employed into specific application and requirements. In this study, N-vinylpyrrolidone (NVP) monomer is utilized via inverse miniemulsion polymerization technique to develop aqueous-soluble polymer nanoparticles with lower toxicity. The effects of different molar ratio of water as polar disperse phase in inverse miniemulsion polymerization of poly(N-vinylpyrrolidone) (PNVP) towards their particle sizes, particle size distributions and morphology were discussed. The formation of PNVP nanoparticles was confirmed by Fourier transform infrared (FTIR) and the morphology was determined using scanning electron microscopy (SEM) and transmission electron microscope (TEM). The particle size of PNVP nanoparticles had mean diameters in the range of 100 – 300 nm depending on the reaction conditions, as measured by dynamic light scattering (DLS). The hydrophilic PNVP nanoparticles obtained were expected to be utilized in biological and medical application especially in drugs delivery as well as a new probe in vivo assessment.

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