The influence of additive amino acid L-phenylalanine on stabilization of metastable α-form of L-glutamic acid was investigated in cooling crystallization. The present study found that the additive L-phenylalanine could be used to stabilize the pure metastable α-form in L-glutamic acid crystallization, where the additive concentration of 0.05-0.1 (g/L) was sufficient to stabilize the 100% wt metastable α-form in solid product at L-glutamic acid concentration of 30-45 (g/L). Additionally, the present results indicated that the adsorption of additive L-phenylalanine on the (001) surface of α-form was more favorable than that of the β-form molecular, so the nucleation sites of stable β-form was occupied by additive molecular, which resulted in inhibition of nucleation and growth of β-form, allowing stabilization of metastable α-form.

1.
J.W.
Mullin
,
Crystallization
(
Oxford Press
,
1993
).
2.
A.S.
Myerson
,
Handbook of Industrial Crystallization
(
Oxford Press
,
1993
).
3.
H.G.
Brittain
,
Polymorphism in Pharmaceutical Solids
(
Marcel Dekker Inc
,
New York
,
1999
).
4.
J
Bernstein
,
Polymorphism in Molecular Crystals
(
Oxford Press
,
2002
).
5.
C.
Cashell
,
D.
Corcoran
, and
B. K.
Hodnett
,
Cryst. Growth. Des
5
,
593
597
(
2005
).
6.
M.
Kitamura
,
T.
Ishizu
,
J. Cryst. Growth
192
,
225
235
(
1998
).
7.
A.T.
Nguyen
,
Y.L.
Joo
and
W.S.
Kim
,
Cryst. Growth. Des
12
,
2780
2788
(
2012
).
8.
A.T.
Nguyen
,
J.M.
Kim
,
S.M.
Chang
and
W.S.
Kim
,
Ind. Eng. Chem. Res
49
,
4865
4872
(
2010
).
9.
A.T.
Nguyen
,
K.
Jeongki
and
W.S.
Kim
,
Ind. Eng. Chem. Res
54
,
5784
5792
(
2015
).
10.
A.T.
Nguyen
,
T.
Yu
and
W.S.
Kim
,
J. Cryst. Growth
469
,
65
77
(
2017
).
11.
M.S.
Lehmann
and
T.F.
Koetzle
,
J. Cryst. Mol. Struct
2
,
225
233
(
1972
).
12.
N.
Hirayama
,
K.
Shirahata
,
Y.
Ohashi
and
Y.
Sasada
,
Bull. Chem. Soc. Jpn
53
,
30
35
(
1980
).
13.
C.Q.
Khuu
,
T.G.
Dang
,
T.T.H.
Trinh
and
A.T.
Nguyen
,
Sci. Tech. Dev
19
,
11
23
(
2016
).
14.
C.A.
Mitchell
,
L.
Yu
and
M.D
Ward
,
J. Am. Chem. Soc
123
,
10830
10839
(
2001
).
This content is only available via PDF.
You do not currently have access to this content.