During the research for bioactive secondary metabolites from microorganisms, the terestrial fungi Aspergillus niger GTS01-4 has been investigated for the evaluation of antimicrobial and cytotoxic activities using brine shrimp (Artemia salina) lethality test and MCF-7 cell line. Further chromatographic separation and purification of myselium extract resulted in the isolation identified as rubrofusarin (1). The structure elucidation of isolated compound was performed using 1D-NMR, and LCMS. Furthermore, the cytotoxicity of rubrofusarin (1) was evaluated and resulted with IC50 of 11.51 µg/mL against MCF-7 and LC50 of 368.11 µg/mL against brine shrimp, respectively. However, rubrofusarin (1) showed moderate activity against E. coli, S. aureus, and B. subtilis compared to standard antibiotic, streptomycin. The average zone of inhibition was ranged from 6 to 8 mm at a concentration of 100 µg/disc. These results suggest that rubrofusarin could be a potential candidate in the field of anticancer drug discovery from terrestrial fungi.
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12 January 2017
INTERNATIONAL SYMPOSIUM ON APPLIED CHEMISTRY (ISAC) 2016
3–5 October 2016
Tangerang Banten, Indonesia
Research Article|
January 12 2017
Rubrofusarin from Aspergillus niger GTS01-4 and its biological activity
Megawati;
Megawati
a
1
Research Center for Chemistry LIPI
, Kawasan PUSPIPTEK, Serpong-Indonesia 15314, Indonesia
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Rizna Triana Dewi;
Rizna Triana Dewi
1
Research Center for Chemistry LIPI
, Kawasan PUSPIPTEK, Serpong-Indonesia 15314, Indonesia
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Hanny Mulyani;
Hanny Mulyani
1
Research Center for Chemistry LIPI
, Kawasan PUSPIPTEK, Serpong-Indonesia 15314, Indonesia
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Faiza Maryani;
Faiza Maryani
1
Research Center for Chemistry LIPI
, Kawasan PUSPIPTEK, Serpong-Indonesia 15314, Indonesia
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Puspa Dewi N. Lotullung;
Puspa Dewi N. Lotullung
1
Research Center for Chemistry LIPI
, Kawasan PUSPIPTEK, Serpong-Indonesia 15314, Indonesia
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Minarti
Minarti
1
Research Center for Chemistry LIPI
, Kawasan PUSPIPTEK, Serpong-Indonesia 15314, Indonesia
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a
Corresponding author: [email protected]
AIP Conf. Proc. 1803, 020026 (2017)
Citation
Megawati, Rizna Triana Dewi, Hanny Mulyani, Faiza Maryani, Puspa Dewi N. Lotullung, Minarti; Rubrofusarin from Aspergillus niger GTS01-4 and its biological activity. AIP Conf. Proc. 12 January 2017; 1803 (1): 020026. https://doi.org/10.1063/1.4973153
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