Progression of tumors and metastasis in particular is one of the main reasons of the high mortality rate among cancer patients. The primary role in developing metastases plays cell locomotion which requires remodeling of the actin cytoskeleton. Form, dynamics, localization and mechanical properties of the actin cytoskeleton are regulated by a variety of actin-binding proteins, which include the adenylyl cyclase-associated protein 1 (CAP1). The study is devoted to the investigation of CAP1 level depending on the presence or absence of metastases in patients with squamous cell carcinoma of the head and neck (SCCHN) and non-small cell lung cancer (NSCLC). The results show the contribution of CAP1 to SCCHN and NSCLC progression. We detected the connection between the tissue protein CAP1 level and the stage of NSCLC and SCCHN disease. Also the levels of the CAP1 protein in tissues of primary tumors and metastases in lung cancer were different. Our data showed that CAP is important in the development of metastases, which suggests further perspectives in the study of this protein for projecting metastasis of NSCLC and SCCHN.
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2 August 2016
PHYSICS OF CANCER: INTERDISCIPLINARY PROBLEMS AND CLINICAL APPLICATIONS (PC’16): Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016
22–25 March 2016
Tomsk, Russia
Research Article|
August 02 2016
Adenylyl cyclase-associated protein 1 in metastasis of squamous cell carcinoma of the head and neck and non-small cell lung cancer Available to Purchase
G. V. Kakurina;
G. V. Kakurina
a)
1
Tomsk Cancer Research Institute
, Kooperativny Street 5, Tomsk, 634050 Russia
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E. S. Kolegova;
E. S. Kolegova
b)
1
Tomsk Cancer Research Institute
, Kooperativny Street 5, Tomsk, 634050 Russia
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O. V. Cheremisina;
O. V. Cheremisina
1
Tomsk Cancer Research Institute
, Kooperativny Street 5, Tomsk, 634050 Russia
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A. A. Zavyalov;
A. A. Zavyalov
1
Tomsk Cancer Research Institute
, Kooperativny Street 5, Tomsk, 634050 Russia
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D. A. Shishkin;
D. A. Shishkin
1
Tomsk Cancer Research Institute
, Kooperativny Street 5, Tomsk, 634050 Russia
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I. V. Kondakova;
I. V. Kondakova
c)
1
Tomsk Cancer Research Institute
, Kooperativny Street 5, Tomsk, 634050 Russia
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E. L. Choinzonov
E. L. Choinzonov
1
Tomsk Cancer Research Institute
, Kooperativny Street 5, Tomsk, 634050 Russia
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G. V. Kakurina
1,a)
E. S. Kolegova
1,b)
O. V. Cheremisina
1
A. A. Zavyalov
1
D. A. Shishkin
1
I. V. Kondakova
1,c)
E. L. Choinzonov
1
1
Tomsk Cancer Research Institute
, Kooperativny Street 5, Tomsk, 634050 Russia
AIP Conf. Proc. 1760, 020023 (2016)
Citation
G. V. Kakurina, E. S. Kolegova, O. V. Cheremisina, A. A. Zavyalov, D. A. Shishkin, I. V. Kondakova, E. L. Choinzonov; Adenylyl cyclase-associated protein 1 in metastasis of squamous cell carcinoma of the head and neck and non-small cell lung cancer. AIP Conf. Proc. 2 August 2016; 1760 (1): 020023. https://doi.org/10.1063/1.4960242
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