The new specialized AFM-probes with hydroxyapatite structures for atomic force microscopy of heart tissues calcification were created and studied. A process of probe fabrication is demonstrated. The adhesive forces between specialized hydroxyapatite probe and endothelium/subendothelial layers were investigated. It was found that the adhesion forces are significantly higher for the subendothelial layers. We consider that it is connected with the formation and localization of hydroxyapatite in the area of subendothelial layers of heart tissues. In addition, the roughness analysis and structure visualization of the endothelial surface of the heart tissue were carried out. The results show high efficiency of created specialized probes at study a calcinations process of the aortic heart tissues.
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17 June 2016
STATE-OF-THE-ART TRENDS OF SCIENTIFIC RESEARCH OF ARTIFICIAL AND NATURAL NANOOBJECTS, STRANN 2016: Proceedings of the 5th International Conference “State-of-the-art trends of scientific research of artificial and natural nanoobjects”
26–29 April 2016
St. Petersburg, Russia
Research Article|
June 17 2016
Specialized probes based on hydroxyapatite calcium for heart tissues research by atomic force microscopy
Mikhail Zhukov;
Mikhail Zhukov
a)
1
St. Petersburg National Research University of Information Technologies
, Mechanics and Optics (ITMO University), Kronverkskii pr. 49, St. Petersburg, 197101, Russia
2
Institute for Analytical Instrumentation
, Russian Academy of Sciences (RAS), Rizhskii pr. 26, St. Petersburg, 190103, Russia
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Nikolai Gulyaev;
Nikolai Gulyaev
3
Military Medical Academy named after S.M. Kirov
, Academic Lebedev str. 6, St. Petersburg, 194044, Russia
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Alexander Golubok
Alexander Golubok
1
St. Petersburg National Research University of Information Technologies
, Mechanics and Optics (ITMO University), Kronverkskii pr. 49, St. Petersburg, 197101, Russia
2
Institute for Analytical Instrumentation
, Russian Academy of Sciences (RAS), Rizhskii pr. 26, St. Petersburg, 190103, Russia
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a)
Corresponding author: [email protected]
AIP Conf. Proc. 1748, 020010 (2016)
Citation
Mikhail Zhukov, Nikolai Gulyaev, Alexander Golubok; Specialized probes based on hydroxyapatite calcium for heart tissues research by atomic force microscopy. AIP Conf. Proc. 17 June 2016; 1748 (1): 020010. https://doi.org/10.1063/1.4954344
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