A model for gamma‐ray emission from large‐scale jets of quasars and active galactic nuclei is proposed. It is shown that if ∼107–1010 M of ambient matter is entrained by the jets in their interaction with the interstellar medium, the π° decay arising from proton collisions can constitute a observable source of gamma ray photons from the jet regions. A relativistic proton spectrum from the black hole, with spectral index between 2 and 2.66 can lead to gamma ray flux densities of the right order of magnitude expected from large scale jets.

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