Simulation of enhanced heating of clinically relevant tissue volumes using nonlinear ultrasound waves generated by a multi-element HIFU phased array were conducted based on the combined Westervelt and bio-heat equations. A spatial spectral approach using the fast Fourier transform algorithm and a corresponding analytic solution to the bioheat equation were used to optimize temperature modeling in tissue. Localized shock-wave heating within a much larger treated tissue volume and short, single HIFU pulses within a much longer overall exposure time were accounted for in the algorithm. Separation of processes with different time and spatial scales made the calculations faster and more accurate. With the proposed method it was shown that for the same time-average power, the use of high peak power pulsing schemes that produce high-amplitude shocks at the focus result in faster tissue heating compared to harmonic, continuous-wave sonications. Nonlinear effects can significantly accelerate volumetric heating while also permitting greater spatial control to reduce the impact on surrounding tissues. Such studies can be further used to test and optimize various steering trajectories of shock-wave sonications for faster and more controlled treatment of tissue volumes.
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28 October 2015
RECENT DEVELOPMENTS IN NONLINEAR ACOUSTICS: 20th International Symposium on Nonlinear Acoustics including the 2nd International Sonic Boom Forum
29 June–3 July 2015
Écully, France
Research Article|
October 28 2015
Use of shock-wave heating for faster and safer ablation of tissue volumes in high intensity focused ultrasound therapy
V. Khokhlova;
V. Khokhlova
a)
1Physics Faculty,
Moscow State University
, Leninskie Gory, 119991 Moscow, Russian Federation
2Center for Industrial and Medical Ultrasound,
University of Washington
, USA
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P. Yuldashev;
P. Yuldashev
b)
1Physics Faculty,
Moscow State University
, Leninskie Gory, 119991 Moscow, Russian Federation
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I. Sinilshchikov;
I. Sinilshchikov
c)
1Physics Faculty,
Moscow State University
, Leninskie Gory, 119991 Moscow, Russian Federation
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A. Partanen;
A. Partanen
3
Clinical Science MR Therapy Philips Healthcare
, Andover, MA, USA
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T. Khokhlova;
T. Khokhlova
2Center for Industrial and Medical Ultrasound,
University of Washington
, USA
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N. Farr;
N. Farr
2Center for Industrial and Medical Ultrasound,
University of Washington
, USA
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W. Kreider;
W. Kreider
1Physics Faculty,
Moscow State University
, Leninskie Gory, 119991 Moscow, Russian Federation
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A. Maxwell;
A. Maxwell
2Center for Industrial and Medical Ultrasound,
University of Washington
, USA
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O. Sapozhnikov
O. Sapozhnikov
1Physics Faculty,
Moscow State University
, Leninskie Gory, 119991 Moscow, Russian Federation
2Center for Industrial and Medical Ultrasound,
University of Washington
, USA
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AIP Conf. Proc. 1685, 040001 (2015)
Citation
V. Khokhlova, P. Yuldashev, I. Sinilshchikov, A. Partanen, T. Khokhlova, N. Farr, W. Kreider, A. Maxwell, O. Sapozhnikov; Use of shock-wave heating for faster and safer ablation of tissue volumes in high intensity focused ultrasound therapy. AIP Conf. Proc. 28 October 2015; 1685 (1): 040001. https://doi.org/10.1063/1.4934396
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