Electroporation is a formation of pores in the membrane cell due to the external electric field applied to the cell. There are two types of electroporation, conventional and supra-electroporation. The purpose of creating pores in the cell using conventional electroporation are to increase the effectiveness of chemotherapy (electrochemotherapy) and to kill cancer tissue using irreversible electroporation. Supra-electroporation shows that it can induce electroporation in the organell inside the cell, so it can kill the cell by apoptosis mechanism. Modeling of electroporation phenomenon on a model cell had been done by using software COMSOL Multiphysics 4.3b with the applied external electric field used are 1.1 kV/cm for conventional electroporation and 60 kV/cm for supra-electroporation to find the difference between transmembrane voltage and pore density for both electroporation. It can be concluded from the results that there is a big difference between transmembrane voltage and pores density on conventional and supra electroporation on model cell.
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Research Article| September 30 2015
Modeling in conventional and supra electroporation for model cell with organelles
Muhammad Yangki Sulaeman;
AIP Conf. Proc. 1677, 100003 (2015)
Muhammad Yangki Sulaeman, Rena Widita; Modeling in conventional and supra electroporation for model cell with organelles. AIP Conf. Proc. 30 September 2015; 1677 (1): 100003. https://doi.org/10.1063/1.4930761
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