We propose a three dimensional model for the adhesion and rolling of biological cells on surfaces. We study cells moving in shear flow above a wall to which they can adhere via specific receptor-ligand bonds based on receptors from selectin as well as integrin family. The computational fluid dynamics are governed by the lattice-Boltzmann method. The movement and the deformation of the cells is described by the immersed boundary method. Both methods are fully coupled by implementing a two-way fluid-structure interaction. The adhesion mechanism is modelled by adhesive bonds including stochastic rules for their creation and rupture. We explore a simplified model with dissociation rate independent of the length of the bonds. We demonstrate that this model is able to resemble the mesoscopic properties, such as velocity of rolling cells.
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10 March 2015
PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON NUMERICAL ANALYSIS AND APPLIED MATHEMATICS 2014 (ICNAAM-2014)
22–28 September 2014
Rhodes, Greece
Research Article|
March 10 2015
A simplified model for dynamics of cell rolling and cell-surface adhesion1)
Ivan Cimrák
Ivan Cimrák
2
Cell-in-fluid Research Group, http://cell-in-fluid.fri.uniza.sk Faculty of Management Science and Informatics,
University of Žilina Univerzitná 8215/1
, 010 26 Žilina, Slovakia
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2
The work of I.Cimrák was supported by the Marie-Curie grant No. PCIG10-GA-2011-303580. Email: ivan.cimrak@fri.uniza.sk
1)
This work was supported by the Slovak Research and Development Agency under the contract No. APVV-0441-11.
AIP Conf. Proc. 1648, 210005 (2015)
Citation
Ivan Cimrák; A simplified model for dynamics of cell rolling and cell-surface adhesion. AIP Conf. Proc. 10 March 2015; 1648 (1): 210005. https://doi.org/10.1063/1.4912490
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