We propose a three dimensional model for the adhesion and rolling of biological cells on surfaces. We study cells moving in shear flow above a wall to which they can adhere via specific receptor-ligand bonds based on receptors from selectin as well as integrin family. The computational fluid dynamics are governed by the lattice-Boltzmann method. The movement and the deformation of the cells is described by the immersed boundary method. Both methods are fully coupled by implementing a two-way fluid-structure interaction. The adhesion mechanism is modelled by adhesive bonds including stochastic rules for their creation and rupture. We explore a simplified model with dissociation rate independent of the length of the bonds. We demonstrate that this model is able to resemble the mesoscopic properties, such as velocity of rolling cells.
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Research Article| March 10 2015
A simplified model for dynamics of cell rolling and cell-surface adhesion1)
AIP Conf. Proc. 1648, 210005 (2015)
Ivan Cimrák; A simplified model for dynamics of cell rolling and cell-surface adhesion. AIP Conf. Proc. 10 March 2015; 1648 (1): 210005. https://doi.org/10.1063/1.4912490
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