Colliding wind binaries (CWBs) are thought to give rise to a plethora of physical processes including acceleration and interaction of relativistic particles. Consequently, CWBs have been considered as putative gamma-ray emitters since the COS-B era. On the basis of 24 months of Fermi-LAT data, seven CWB systems are analyzed: WR 11, WR 70, WR 125, WR 137, WR 140, WR 146 and WR 147. Specific theoretical predictions for the gamma-ray emission of CWBs identify these systems as the most promising candidates among known WR-binaries due to their respective stellar and orbital parameters. We find no evidence of gamma-ray emission from any of the studied CWB systems and flux upper limits are determined. In some of the studied CWBs the interplay of orbital and stellar parameters render the Fermi data as not sufficiently sensitive to constrain parameters of the emission model. In others large uncertainties in input parameters of the gamma-ray emission model yield a large variance among model parameters that can be accommodated by the data. However, in the case of WR 140 and WR 147, the Fermi upper limits appear to rule out some early model predictions and constrain later theoretical models over a significant parameter space.

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