Hypothyroid has been associated to a disruption of the body's metabolism, including the healing process. Laser and LED have been shown to be effective on improving healing in many situations, but their benefit in the improvement of healing on hypothyroidism remains unknown. The aim of this study was to assess, morphometrically, the influence of Laser (λ660nm, 24 J/cm2, 40mW, CW, spot output= 4mm2;) and LED (λ630nm ± 20, 24 J/cm2, 150mW, CW, spot output= 0.5 cm2) on the wound healing of rats with Hypothyroid. Under general anesthesia, a standard surgical wound (1cm2) was created on the dorsum of 72 male Wistar rats divided into 6 groups of 12 animals each: G1: Euthyroid; G2: Euthyroid + Laser; G3: Euthyroid + LED; G4: Hypothyroid; G5: Hypothyroid + Laser and G6: Hypothyroid + LED. Hypothyroidism was induced in rats with propylthiouracil (0.05g/100mL) administered orally for 4 weeks and maintained until the end of the experiment. Rats were irradiated after surgery each 48h then killed after 7 and 14 days. Statistical analysis was performed using ANOVA and Tukey's test. Hypothyroid rats with phototherapy laser or LED showed significant less wound contraction than euthyroid's rats at the 7th day (p<0.05). At the 14th day, the longitudinal measurement was significantly higher in euthyroids (control and irradiated with laser) when compared to the hypothyroid group (p <0.05). This study has shown that hypothyroidism delays wound healing and Laser and LED photobiomodulation using 24 J/cm2 per session improved cutaneous wound healing in hypothyroid rats.
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26 September 2012
ADVANCES IN LASEROLOGY - SELECTED PAPERS OF LASER FLORENCE 2011: A Window on the Laser Medicine World
4–5 November 2011
Firenze, Italy
Research Article|
September 26 2012
Assessment of the effects of laser or LED photobiomodulation on hypothyroid rats of cutaneous wound healing: A morphometric study.
Isabele Cardoso Vieira De Castro;
Isabele Cardoso Vieira De Castro
Center of Biophotonics, School of Dentistry, Federal University of Bahia, 62 Araujo Pinho Ave, Canela, Salvador, BA, Brazil, 40110--150,
Brazil
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Gardênia Matos Paraguassú;
Gardênia Matos Paraguassú
Center of Biophotonics, School of Dentistry, Federal University of Bahia, 62 Araujo Pinho Ave, Canela, Salvador, BA, Brazil, 40110--150,
Brazil
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João Alves dod Reis Júnior;
João Alves dod Reis Júnior
Center of Biophotonics, School of Dentistry, Federal University of Bahia, 62 Araujo Pinho Ave, Canela, Salvador, BA, Brazil, 40110--150,
Brazil
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Flávia Caló Aquino Xavier;
Flávia Caló Aquino Xavier
Laboratório de Patologia cirúrgica, Federal University of Bahia, 62 Araujo Pinho Ave, Canela, Salvador,BA, Brazil, 40110--150,
Brazil
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Tânia Tavares Rodriguez;
Tânia Tavares Rodriguez
Health Sciences Institute, Federal University of Bahia, Reitor Miguel Calmon Ave, Vale do Canela Salvador, BA, Brazil, 40110100,
Brazil
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Maria José Pedreira Ramalho;
Maria José Pedreira Ramalho
Center of Biophotonics, School of Dentistry, Federal University of Bahia, 62 Araujo Pinho Ave, Canela, Salvador, BA, Brazil, 40110--150 and Laboratório de Patologia cirúrgica, Federal University of Bahia, 62 Araujo Pinho Ave, Canela, Sa,
Brazil
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Antônio L. B. Pinheiro;
Antônio L. B. Pinheiro
Center of Biophotonics, School of Dentistry, Federal University of Bahia, 62 Araujo Pinho Ave, Canela, Salvador, BA, Brazil, 40110-150 and Centro de Engénharia Biomedica - Unicastelo, Parque Tecnológico de São José dos Cam,
Brazil
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Luciana Maria Pedreira Ramalho
Luciana Maria Pedreira Ramalho
Center of Biophotonics, School of Dentistry, Federal University of Bahia, 62 Araujo Pinho Ave, Canela, Salvador, BA, Brazil, 40110-150 and Laboratório de Patologia cirúrgica, Federal University of Bahia, 62 Araujo Pinho Ave, Canela, Sal,
Brazil
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Isabele Cardoso Vieira De Castro
Gardênia Matos Paraguassú
João Alves dod Reis Júnior
Flávia Caló Aquino Xavier
Tânia Tavares Rodriguez
Maria José Pedreira Ramalho
Antônio L. B. Pinheiro
Luciana Maria Pedreira Ramalho
Center of Biophotonics, School of Dentistry, Federal University of Bahia, 62 Araujo Pinho Ave, Canela, Salvador, BA, Brazil, 40110--150,
Brazil
AIP Conf. Proc. 1486, 95–99 (2012)
Citation
Isabele Cardoso Vieira De Castro, Gardênia Matos Paraguassú, João Alves dod Reis Júnior, Flávia Caló Aquino Xavier, Tânia Tavares Rodriguez, Maria José Pedreira Ramalho, Antônio L. B. Pinheiro, Luciana Maria Pedreira Ramalho; Assessment of the effects of laser or LED photobiomodulation on hypothyroid rats of cutaneous wound healing: A morphometric study.. AIP Conf. Proc. 26 September 2012; 1486 (1): 95–99. https://doi.org/10.1063/1.4757828
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