Background: Oral mucositis remains one of the most common and troubling side effects of antineoplastic radiation and drug therapy: its incidence in onco-hematological radio-chemotreated patients is variable between 50 and 100% and its impact on this populations is directly linked with the experience of intense pain causing reduction and modification of therapy regimens, decreased survival rates and increased cost of care. Purpose: Aim of this study is the preliminary evaluation of a Low Level Laser therapy (LLLT) protocol on healing process of oral mucositis and on pain and quality of life of patients experiencing this dramatic side-effect. Materials and methods: Patients were evaluated and treated at the Unita` Operativa Semplice Dipartimentale di Odontostomatologia e Chirurgia Maxillo-Facciale of the Hospital of Piacenza were they were treated for primary disease with protocols of chemotherapy and/or radiotherapy. LLLT protocol was performed with a diode laser (808 nm -XD Smile - Fotona -Slovenia) on a two weeks-6 treatments schedule with power of 0.5 W and application of 30 seconds. Mucositis grading was scored on the basis of WHO classification by two blind operators at each treatment and at 1 and 2 weeks after treatment. Pain and capability of deglutition were described by patients by means questionnaires based on Visual Analogue Scale, Numerical Rating Scale and Quality of Life. Results: A relevant improvement of healing of oral mucositis, in terms of reduction of grading score, and of pain, swallowing discomfort and quality of life was recorded. Discussion and conclusion: Results of this preliminary study are encouraging for the realization of larger studies focused on the application of LLLT protocols in management of radio-chemotreated patients with oral mucositis.
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26 September 2012
ADVANCES IN LASEROLOGY - SELECTED PAPERS OF LASER FLORENCE 2011: A Window on the Laser Medicine World
4–5 November 2011
Firenze, Italy
Research Article|
September 26 2012
Preliminary study on radio-chemo-induced oral mucositis and low level laser therapy Available to Purchase
Elisabetta Merigo;
Elisabetta Merigo
U.O.S.D. di Odontostomatologia e Chirurgia Maxillo-Facciale - Ospedale Guglielmo da Saliceto - via Taverna, 49, 29100 - Piacenza, Italy and EMDOLA - Università di Parma - via Gramsci, 14, 43100 - Parma,
Italy
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Matteo Fontana;
Matteo Fontana
U.O.S.D. di Odontostomatologia e Chirurgia Maxillo-Facciale - Ospedale Guglielmo da Saliceto - via Taverna, 49, 29100 - Piacenza,
Italy
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Carlo Fornaini;
Carlo Fornaini
EMDOLA - Università di Parma - via Gramsci, 14, 43100 - Parma,
Italy
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Fabio Clini;
Fabio Clini
U.O.S.D. di Odontostomatologia e Chirurgia Maxillo-Facciale - Ospedale Guglielmo da Saliceto - via Taverna, 49, 29100 - Piacenza,
Italy
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Luigi Cella;
Luigi Cella
U.O.S.D. di Odontostomatologia e Chirurgia Maxillo-Facciale - Ospedale Guglielmo da Saliceto - via Taverna, 49, 29100 - Piacenza,
Italy
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Paolo Vescovi;
Paolo Vescovi
EMDOLA - Università di Parma - via Gramsci, 14, 43100 - Parma,
Italy
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Aldo Oppici
Aldo Oppici
U.O.S.D. di Odontostomatologia e Chirurgia Maxillo-Facciale - Ospedale Guglielmo da Saliceto - via Taverna, 49, 29100 - Piacenza,
Italy
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Elisabetta Merigo
U.O.S.D. di Odontostomatologia e Chirurgia Maxillo-Facciale - Ospedale Guglielmo da Saliceto - via Taverna, 49, 29100 - Piacenza, Italy and EMDOLA - Università di Parma - via Gramsci, 14, 43100 - Parma,
Italy
Matteo Fontana
U.O.S.D. di Odontostomatologia e Chirurgia Maxillo-Facciale - Ospedale Guglielmo da Saliceto - via Taverna, 49, 29100 - Piacenza,
Italy
Carlo Fornaini
EMDOLA - Università di Parma - via Gramsci, 14, 43100 - Parma,
Italy
Fabio Clini
U.O.S.D. di Odontostomatologia e Chirurgia Maxillo-Facciale - Ospedale Guglielmo da Saliceto - via Taverna, 49, 29100 - Piacenza,
Italy
Luigi Cella
U.O.S.D. di Odontostomatologia e Chirurgia Maxillo-Facciale - Ospedale Guglielmo da Saliceto - via Taverna, 49, 29100 - Piacenza,
Italy
Paolo Vescovi
EMDOLA - Università di Parma - via Gramsci, 14, 43100 - Parma,
Italy
Aldo Oppici
U.O.S.D. di Odontostomatologia e Chirurgia Maxillo-Facciale - Ospedale Guglielmo da Saliceto - via Taverna, 49, 29100 - Piacenza,
Italy
AIP Conf. Proc. 1486, 137–141 (2012)
Citation
Elisabetta Merigo, Matteo Fontana, Carlo Fornaini, Fabio Clini, Luigi Cella, Paolo Vescovi, Aldo Oppici; Preliminary study on radio-chemo-induced oral mucositis and low level laser therapy. AIP Conf. Proc. 26 September 2012; 1486 (1): 137–141. https://doi.org/10.1063/1.4757833
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