Nowadays, nanofiber made of polymers becomes popular on biomaterials research. One of the main reasons to need of nanofiber size is to mimic extracellular matrix (ECM) that play a critical role in proliferation, cell motility and intercellular signaling in vascular graft replacement. In this study polyurethane (PU) is electrospuned for 1 hour to create a scaffold under different conditions. The average diameter of the electrospun nanofibers was determined by analyzing the SEM images using imageJ analysis program. For this purpose, a general full factorial in completely randomized design using three levels of two factors; power ( 22 and 25 Watts) and feeding rate ( 1.25 and 1.50 ml/h) was used to evaluate the response pattern and to determine the combined effect of independent variables. Three replicates were performed. The collected data were analyzed by using ANOVA test. Using the main effects for power (W) and feeding rate (V) and the power (W)*feeding rate (V) interaction are statistically significant. Based on the statistical results of the experiment, we recommend for finer fiber 22 W and 1.00 ml/h and for less beads a 20 W and 1.50 ml/h to made PU scaffold. SEM analysis confirms a formation of random nanofiber mats.
The Effects of Power and Feeding Rate on Production of Polyurethane Nanofiber with Electrospinning Process
Mustafa Ö. Öteyaka, Emre Özel, M. Mustafa Yıldırım; The Effects of Power and Feeding Rate on Production of Polyurethane Nanofiber with Electrospinning Process. AIP Conf. Proc. 26 December 2011; 1400 (1): 216–221. https://doi.org/10.1063/1.3663116
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