Nowadays, nanofiber made of polymers becomes popular on biomaterials research. One of the main reasons to need of nanofiber size is to mimic extracellular matrix (ECM) that play a critical role in proliferation, cell motility and intercellular signaling in vascular graft replacement. In this study polyurethane (PU) is electrospuned for 1 hour to create a scaffold under different conditions. The average diameter of the electrospun nanofibers was determined by analyzing the SEM images using imageJ analysis program. For this purpose, a 3×3 general full factorial in completely randomized design using three levels of two factors; power (W = 20, 22 and 25 Watts) and feeding rate (V = 1.00, 1.25 and 1.50 ml/h) was used to evaluate the response pattern and to determine the combined effect of independent variables. Three replicates were performed. The collected data were analyzed by using ANOVA test. Using α = 0.05, the main effects for power (W) and feeding rate (V) and the power (W)*feeding rate (V) interaction are statistically significant. Based on the statistical results of the experiment, we recommend for finer fiber 22 W and 1.00 ml/h and for less beads a 20 W and 1.50 ml/h to made PU scaffold. SEM analysis confirms a formation of random nanofiber mats.

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