Hind‐limb suspension (HLS) of rats is a NASA validated model of simulated weightlessness. This study examines the effects of microgravity on the skeletal system of rats to assess whether or not exposure of rats to HLS for one week will induce alteration of structural features in selected bones. Four groups of rats were used: two unsuspended controls and two suspended groups. Body weight, food, and water intake were monitored daily before and after suspension. X‐rays were measured by a liquid nitrogen cooled Si(li) detector on a Scanning Electron Microscope (SEM) that provided the 20 keV electron beam. X‐ray data were collected from square cross sections between and The bones were measured for elemental levels of calcium, phosphorus, oxygen and carbon from both control and HLS rats. The average body weight of all HLS groups decreased compared to their respective unsuspended controls. Food and water intake was also lower in both suspended groups. A correlation among HLS and control samples in terms of the distribution of the primary elements was found in the bone tissue when analyzed as a function of position along the hind‐leg and within the cross sections.
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12 April 2010
BIOLOGY, NANOTECHNOLOGY, TOXICOLOGY AND APPLICATIONS: 4th BioNanoTox (Biology, Nanotechnology, Toxicology) and Applications
21–22 October 2009
Little Rock (Arkansas)
Research Article|
April 12 2010
ANALYSIS OF 20 KEV ELECTRON INDUCED X‐RAY PRODUCTION IN SKULL, FEMUR/TIBIA BONES OF RATS
Rahul Mehta;
Rahul Mehta
aDepartment of Physics and Astronomy, University of Central Arkansas, Conway, Arkansas USA
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Alec Watson;
Alec Watson
aDepartment of Physics and Astronomy, University of Central Arkansas, Conway, Arkansas USA
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Nawab Ali;
Nawab Ali
bGraduate Institute of Technology, University of Arkansas at Little Rock, Little Rock, Arkansas, USA
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Michael Soulsby;
Michael Soulsby
cDepartment of Physiology and Biophysics, University of Arkansas for Medical Science, Little Rock, Arkansas, USA
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Parimal Chowdhury
Parimal Chowdhury
cDepartment of Physiology and Biophysics, University of Arkansas for Medical Science, Little Rock, Arkansas, USA
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AIP Conf. Proc. 1229, 73–79 (2010)
Citation
Rahul Mehta, Alec Watson, Nawab Ali, Michael Soulsby, Parimal Chowdhury; ANALYSIS OF 20 KEV ELECTRON INDUCED X‐RAY PRODUCTION IN SKULL, FEMUR/TIBIA BONES OF RATS. AIP Conf. Proc. 12 April 2010; 1229 (1): 73–79. https://doi.org/10.1063/1.3419704
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