In the past years, many scientific and economic‐related applications from various domains have taken advantage of Grid infrastructures that share storage or computational resources such as supercomputers or clusters across multiple organizations. Especially within Grid infrastructures driven by high‐performance computing (HPC) such as the Distributed European Infrastructure for Supercomputing Applications (DEISA), the UNICORE Grid middleware has become an important tool to seamlessly access distributed resources by providing strong security and workflow capabilities. This paper highlights different usage models of UNICORE from a wide variety of scientific applications, and provides insights of approaches in economic‐related scenarios with UNICORE.

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