The aim of this paper is to demonstrate how multilevel tumour growth and response to therapeutic treatment models can be used in order to simulate clinical trials, with the long‐term intention of both better designing clinical studies and understanding their outcome based on basic biological science. For this purpose, an already developed computer simulation model of glioblastoma multiforme response to radiotherapy has been used and a clinical study concerning glioblastoma multiforme response to radiotherapy has been simulated. In order to facilitate the simulation of such virtual trials, a toolkit enabling the user‐friendly execution of the simulations on grid infrastructures has been designed and developed. The results of the conducted virtual trial are in agreement with the outcome of the real clinical study.
In Silico Simulation of a Clinical Trial Concerning Tumour Response to Radiotherapy
Dimitra D. Dionysiou, Georgios S. Stamatakos, Theodoras E. Athanaileas, Andreas Merrychtas, Dimitra Kaklamani, Theodora Varvarigou, Nikolaos Uzunoglu; In Silico Simulation of a Clinical Trial Concerning Tumour Response to Radiotherapy. AIP Conf. Proc. 6 November 2008; 1060 (1): 94–97. https://doi.org/10.1063/1.3037123
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