Extracorporeal shock wave lithotripsy (SWL) can injure tissue and decrease blood flow in the SWL‐treated kidney, both tissue and functional effects being largely localized to the region targeted with shock waves (SWs). A novel method of limiting SWL‐induced tissue injury is to employ the “protection” protocol, where the kidney is pretreated with low‐energy SWs prior to the application of a standard clinical dose of high‐energy SWs. Resistive index measurements of renal vascular resistance/impedance to blood flow during SWL treatment protocols revealed that a standard clinical dose of high‐energy SWs did not alter RI during SW application. However, there was an interaction between low‐ and high‐energy SWL treatment phases of the “protection” protocol such that an increase in RI (vasoconstriction) was observed during the later half of SW application, a time when tissue damage is occurring during the standard high‐energy SWL protocol. We suggest that renal vasoconstriction may be responsible for reducing the degree of tissue damage that normally results from a standard clinical dose of high‐energy SWs.
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18 September 2008
RENAL STONE DISEASE 2: 2nd International Urolithiasis Research Symposium
17–18 April 2008
Indianapolis (Indiana)
Research Article|
September 18 2008
Effect of Shock Wave Lithotripsy on Renal Hemodynamics
Rajash K. Handa;
Rajash K. Handa
aDepartments of Anatomy & Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Bldg, Indianapolis, IN 46202, USA
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Lynn R. Willis;
Lynn R. Willis
bDepartments of Pharmacology & Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Bldg, Indianapolis, IN 46202, USA
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Andrew P. Evan;
Andrew P. Evan
aDepartments of Anatomy & Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Bldg, Indianapolis, IN 46202, USA
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Bret A. Connors
Bret A. Connors
aDepartments of Anatomy & Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Bldg, Indianapolis, IN 46202, USA
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Rajash K. Handa
a
Lynn R. Willis
b
Andrew P. Evan
a
Bret A. Connors
a
aDepartments of Anatomy & Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Bldg, Indianapolis, IN 46202, USA
bDepartments of Pharmacology & Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Sciences Bldg, Indianapolis, IN 46202, USA
AIP Conf. Proc. 1049, 249–255 (2008)
Citation
Rajash K. Handa, Lynn R. Willis, Andrew P. Evan, Bret A. Connors; Effect of Shock Wave Lithotripsy on Renal Hemodynamics. AIP Conf. Proc. 18 September 2008; 1049 (1): 249–255. https://doi.org/10.1063/1.2998031
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